Advertisement
Review Article|Articles in Press

Lessons Learned from Health Disparities in Coronavirus Disease-2019 in the United States

Published:November 21, 2022DOI:https://doi.org/10.1016/j.ccm.2022.11.021

      Keywords

      Key points

      • The coronavirus disease-2019 (COVID-19) pandemic has disproportionally affected historically marginalized populations, including minorities, immigrants, and economically disadvantaged individuals.
      • COVID-19 cases, hospitalizations, and deaths are higher in Black, Latinx, and Indigenous populations than in non-Latinx white individuals, yet vaccination rates in minority groups are lower than the national average.
      • COVID-19 disparities are rooted in longstanding health inequities due to structural determinants of health (eg, racism, low socioeconomic status) that affect education, housing, employment, and access to high-quality health care.
      • Short-term (eg, subsidies for heavily affected communities) and long-term (eg, universal health care) policies to mitigate the negative impact of structural and socioeconomic barriers have the potential to reduce health disparities in general, and for COVID-19 outcomes in particular.

      Introduction

      As of June 2022, 2 years into the coronavirus disease-2019 (COVID-19) pandemic, 84.2 million people in the United States have been infected, and over 1 million have died.
      Center for Disease Control and Prevention
      United States COVID-19 cases, deaths, and laboratory testing (NAATs) by state, territory, and jurisdiction.
      The impact of this calamity has been felt across our society, but the burden of hospitalizations and deaths has disproportionally affected historically marginalized populations, including minorities, immigrants, and economically disadvantaged individuals. Black, Latinx, and Indigenous populations have the infection and death rates higher than non-Latinx White groups (heretofore referred to as “White”).
      • Mackey K.
      • Ayers C.K.
      • Kondo K.K.
      • et al.
      Racial and ethnic disparities in COVID-19-related infections, hospitalizations, and deaths : a systematic review.
      ,
      • Hatcher S.M.
      • Agnew-Brune C.
      • Anderson M.
      • et al.
      COVID-19 among American Indian and Alaska native persons - 23 states, january 31-july 3, 2020.
      As we have passed the grim 1-million death mark for the ongoing pandemic, the age-adjusted death rates from COVID-19 in younger people are approximately twice as high in Black and Latinx populations than in White groups.
      • Wortham J.M.
      • Lee J.T.
      • Althomsons S.
      • et al.
      Characteristics of persons who died with COVID-19 - United States, february 12-may 18, 2020.
      In the first year of the pandemic, vaccines were quickly developed and became an effective tool to reduce transmission, hospitalization, and deaths from COVID-19. Since the initial rollout, however, vaccination rates have been lower in Black and Latinx communities. As of June 2022, only 48% and 63% of eligible Black and Latinx people have received at least one vaccine dose, well below the national average of 78%. Among Black and Latinx populations, a long-standing mistrust in the health care system and the research enterprise, language barriers, immigration issues, and lack of health insurance in low-paying jobs magnified non-access to vaccines.
      • Diaz A.A.
      • Celedon J.C.
      COVID-19 vaccination: helping the latinx community to come forward.
      Health disparities during the COVID-19 pandemic are not random but rather due to longstanding racial/ethnic and socioeconomic inequities caused by structural racism and discriminatory policies regarding access to high-quality education, employment, housing, and health care.
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      Although access to health care improved following the passage of the Affordable Care Act, millions of people remain uninsured, which compromises the capacity of the US health care system to deliver equitable care, particularly in a health crisis. Moreover, the pandemic overwhelmed hospitals that predominantly care for Black, Latinx, and Indigenous communities, exacerbating already strained, low-resourced health systems and limiting access to advanced treatments and critical care services. This article discusses the challenges faced by marginalized and underserved populations, and the lessons learned from the COVID-19 pandemic.

      Structural and Social Determinants of Health

      Structural and social determinants of health (SDOH) are “the circumstances in which people live and the systems and structures that model their experience and access to health care.”
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      In prior work, we have used the World Health Organization (WHO) Conceptual framework for Action on Social Determinants of Health (WHO CSDH)
      • Solar O.
      • Inwin A.
      A conceptual framework for action on the social determinants of health: social determinants of health discussion paper 2.
      to simultaneously examine root causes of existing disparities while also identifying opportunities for action (Fig. 1).
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      This framework proposes that structural bases (eg, social class) impact the socioeconomic and political context (eg, government, policies, and cultures), influencing structural determinants (eg, policies, socioeconomic status, and racism), which shape exposure to intermediary social determinants. The intermediary determinants include health care access, occupational and housing conditions, and psychosocial stress that, in the end, determine an individual’s unique social circumstances that shape behavior and risk for disease.
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      This framework helps us evaluate the immediate circumstances of living while also considering the broader context that impacted COVID-19 outcomes. This article focuses on structural determinants that were essential drivers of health disparities during the COVID-19 pandemic.
      Figure thumbnail gr1
      Fig. 1Structural and social determinants of health contributing to the racial and ethnic disparities in the coronavirus disease (COVID-19) pandemic in the United States and proposed areas for action, as informed by the World Health Organization Conceptual Framework for Action. PPE, personal protective equipment.
      (From Thakur N, Lovinsky-Desir S, Bime C, Wisnivesky JP, Celedón JC. The Structural and Social Determinants of the Racial/Ethnic Disparities in the U.S. COVID-19 Pandemic. What's Our Role?. Am J Respir Crit Care Med. 2020;202(7):943-949.)

      Disparities in Coronavirus Disease-2019 Infection

      Since the early phases of the pandemic, COVID-19 has disproportionally affected minorities living in hotspot counties. The mean difference between the proportion of cases and the proportion of the population was 30.2% and 14.5% for Blacks and Latinx, respectively.
      • Moore J.T.
      • Ricaldi J.N.
      • Rose C.E.
      • et al.
      Disparities in incidence of COVID-19 among underrepresented racial/ethnic groups in counties identified as hotspots during June 5–18, 2020 — 22 states february–june 2020.
      In California, Latinx residing in less-advantaged neighborhoods (ie, low median household income, low median educational attainment, and high household density) experienced exponential growth in COVID-19 cases during a 6-week period of observation at the beginning of the pandemic, with the highest increase in low-income areas.

      Chow DS, Soun J, Gavis-Bloom J, et al. The disproportionate rise in COVID-19 cases among Hispanic/Latinx in disadvantaged communities of Orange County, California: A socioeconomic case-series. Pre-print. Posted online on 7 May 2020. medRxiv. doi: 10.1101/2020.05.04.20090878.

      This observation was also seen in cities across the United States (eg, Chicago, New York City, Philadelphia, and Newark), where the number of reported COVID-19 was higher in less-advantaged neighborhoods than in more-advantaged ones.
      • Okoh A.K.
      • Sossou C.
      • Dangayach N.S.
      • et al.
      Coronavirus disease 19 in minority populations of Newark, New Jersey.
      Compared with the rates of COVID-19 in White populations, those in Black and Latinx populations were 1.5 to 3.5 times and 1.3 to 28 times higher, respectively.
      • Mackey K.
      • Ayers C.K.
      • Kondo K.K.
      • et al.
      Racial and ethnic disparities in COVID-19-related infections, hospitalizations, and deaths : a systematic review.
      ,
      • Adegunsoye A.
      • Ventura I.B.
      • Liarski V.M.
      Association of black race with outcomes in COVID-19 disease: a retrospective cohort study.
      Community transmission was up to 28 times higher for Latinx than White populations, whereas in the hospital or health care settings Latinx had 1.3 to 7.7 times higher risk for COVID-19 than White populations.
      • Mackey K.
      • Ayers C.K.
      • Kondo K.K.
      • et al.
      Racial and ethnic disparities in COVID-19-related infections, hospitalizations, and deaths : a systematic review.
      Fig. 2 shows that, regardless of the timepoint in the pandemic, Latinx (green line) and American Indians/Alaska Natives (yellow line) generally had the highest incident cases from early 2020 to June of 2022.
      Center for Disease Control and Prevention
      COVID-19 weekly cases and deaths per 100,000 population by age, race/ethnicity, and sex.
      Figure thumbnail gr2
      Fig. 2COVID-19 weekly cases per 100,000 population by race/ethnicity, United States, March 1, 2020-June 4, 2022. Percentage of cases reporting race, 63.1%. Demographic data for COVID-19 cases is based on a subset of individuals where state and territorial jurisdictions have reported case-level data to the CDC since January 21, 2020. Demographic data have varying degrees of missing data and are not generalizable to the entire population of individuals with COVID-19. All displayed counts include confirmed COVID-19 cases as reported by US states, US territories, New York City (NYC), and the District of Columbia from the previous day. Counts for certain jurisdictions also include probable COVID-19 cases. Case rates displayed for the week ending 08/07/2021 reflect a large data influx. The clinical dates for these data were not available. These data are provisional and will be updated as CDC receives additional information. AI/AN, American Indian/Alaska Native; NH, non-hispanic; PI, Pacific Islander.
      (From Center for Disease Control and Prevention. COVID-19 Weekly Cases and Deaths per 100,000 Population by Age, Race/Ethnicity, and Sex. Available at: https://covid.cdc.gov/covid-data-tracker/#demographicsovertime. Accessed Jun 3 2022.)
      Several structural and socioeconomic factors (neighborhood and household characteristics, income, education, and work conditions) have fueled disease transmission. Black and Latinx populations are disproportionately represented among the poor and are more likely to be frontline workers with low-paying jobs, leading to high levels of COVID-19 exposure but limited job-sponsored benefits.
      • Diaz A.A.
      • Celedon J.C.
      COVID-19 vaccination: helping the latinx community to come forward.
      ,
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      Nearly half of Black and Latinx female health care workers earn <$15 per hour, and more than 10% are uninsured.
      • Himmelstein K.E.W.
      • Venkataramani A.S.
      Economic vulnerability among us female health care workers: potential impact of a $15-per-hour minimum wage.
      Black individuals are less likely to telecommute and more likely to work in the service sector and to use public transportation than members of other racial/ethnic groups (Black, 23%; Latinx, 15%; and White, 7%).
      • Anderson M.
      Who relies on public transit in the U.S. Pew Research Center.
      Moreover, Black individuals were more likely to report leaving the home in the prior 3 days of infection than White individuals,
      • Alsan M.
      • Stantcheva S.
      • Yang D.
      • et al.
      Disparities in coronavirus 2019 reported incidence, knowledge, and behavior among US adults.
      increasing opportunities for transmission. Fueled by economic hardship, Latinx immigrants continued to work in high-transmission jobs while expressing gratitude that lockdown orders did not extend to their construction, cleaning, and cooking jobs, as they were often ineligible for unemployment benefits or income relief because of their legal status.
      • Page K.R.
      • Flores-Miller A.
      Lessons we've learned - covid-19 and the undocumented latinx community.
      Unstable housing compounded the situation, with low-income immigrants and work acquittances sharing residences to reduce cost, exacerbating disease risk, and making self-isolation to curb disease transmission difficult or impossible.
      • Page K.R.
      • Flores-Miller A.
      Lessons we've learned - covid-19 and the undocumented latinx community.
      Racial/ethnic differences in COVID-19 infection rates are also observed in the elderly, a high-risk group. An analysis of the Center for Medicare and Medicaid Services (CMS) data between January 1, 2020, and November 20, 2021, showed that over 6 million beneficiaries tested positive for COVID-19 at an infection rate of 9,587 cases per 100,000 population,
      Centers for Medicare and Medicaid Services
      Preliminary Medicare COVID-19 data snapshot.
      with some minority groups having the highest rates: Indigenous Populations, 14,413; Latinx, 12,300; Black, 11,182; White, 9,242; Other/Unknown Race, 7,017; and Asian/Pacific Islander, 6,101.
      Centers for Medicare and Medicaid Services
      Preliminary Medicare COVID-19 data snapshot.
      The case rate was much higher in beneficiaries with both Medicare and Medicaid Services than in those with Medicare alone (7,936 vs 16,583 per 100,000).
      Centers for Medicare and Medicaid Services
      Preliminary Medicare COVID-19 data snapshot.
      People having both services were generally impoverished and experienced higher rates of chronic illness and need for long-term care than those with only Medicare.
      Centers for Medicare and Medicaid Services
      Preliminary Medicare COVID-19 data snapshot.
      Black, Indigenous, Latinx, and economically disadvantaged individuals are 1.1 to 2.8 times more likely to be at high risk for complications from COVID-19 infection by virtue of comorbidities than White or high-income individuals.
      • Gaffney A.W.
      • Hawks L.
      • Bor D.H.
      • et al.
      18.2 million individuals at increased risk of severe COVID-19 illness are un- or underinsured.
      This high-risk group includes approximately 18.2 million people who may be uninsured or underinsured,
      • Gaffney A.W.
      • Hawks L.
      • Bor D.H.
      • et al.
      18.2 million individuals at increased risk of severe COVID-19 illness are un- or underinsured.
      a condition more common in Black and Latinx individuals than in their White counterparts.
      • Gaffney A.W.
      • Hawks L.
      • Bor D.H.
      • et al.
      18.2 million individuals at increased risk of severe COVID-19 illness are un- or underinsured.
      Despite the positive impact of the Affordable Care Act, one in five Latinx or Indigenous people under 65 years still lacks health insurance.
      • Artiga S.
      • Hill L.
      • Orgera K.
      • et al.
      The intersection of different structural factors—socioeconomic status, race/ethnicity, English language proficiency, housing type and transportation, and household composition and disability—are included in the Social Vulnerability Index of CDC, a validated measure of community resiliance during disease outbreaks.
      • Khazanchi R.
      • Beiter E.R.
      • Gondi S.
      • et al.
      County-level association of social vulnerability with COVID-19 cases and deaths in the USA.
      The conjunction of adverse structural factors impact exposure and disease risk. People living in the most vulnerable counties, which were driven by minority status and non-English language use, had a greater risk of COVID-19 diagnosis than those in the least vulnerable counties (Fig. 3).
      • Khazanchi R.
      • Beiter E.R.
      • Gondi S.
      • et al.
      County-level association of social vulnerability with COVID-19 cases and deaths in the USA.
      Figure thumbnail gr3
      Fig. 3COVID-19 cases per capita between most and least socially disadvantaged counties. This data represents cases from the onset of the pandemic through April 19, 2020. The most vulnerable quartile of counties (n = 706, top) and the least vulnerable quartile of counties (n = 625, bottom), as indicated by the minority status and language domain of the US Centers for Disease Control’s Social Vulnerability Index. Counties without linked Federal Information Processing Standard code or reported COVID-19 cases were excluded. Darker shades represent counties with more cases per capita.
      (From Khazanchi R, Beiter ER, Gondi S, Beckman AL, Bilinski A, Ganguli I. County-Level Association of Social Vulnerability with COVID-19 Cases and Deaths in the USA. J Gen Intern Med. 2020;35(9):2784-2787.)

      Disparities in Coronavirus Disease-2019 Outcomes

      Most people affected with COVID-19 present with mild disease or are asymptomatic, whereas some became severely ill and require hospitalization. The risk of severe illness and death from COVID-19 is higher in the unvaccinated and older adults.
      Early in the pandemic, CDC data showed that Black and Latinx populations each had hospitalization rates ∼4.5 times higher than White populations.
      Centers for Disease Control and Prevention
      COVID view summary ending on June 20, 2020.
      ,
      • Gold J.A.W.
      • Wong K.K.
      • Szablewski C.M.
      • et al.
      Characteristics and clinical outcomes of adult patients hospitalized with COVID-19 - Georgia, March 2020.
      A single-hospital study that included mostly Black and Latinx patients demonstrated that Latinx patients were more likely to be hospitalized than White patients.
      • Hsu H.E.
      • Ashe E.M.
      • Silverstein M.
      • et al.
      Race/ethnicity, underlying medical conditions, homelessness, and hospitalization status of adult patients with COVID-19 at an urban safety-net medical center - Boston, Massachusetts, 2020.
      This early trend continued throughout the pandemic, with a systematic review reporting that Black and Latinx populations were 1.5 to 3 and 1.5 times, respectively, more likely to be hospitalized than White populations in 2021.
      • Mackey K.
      • Ayers C.K.
      • Kondo K.K.
      • et al.
      Racial and ethnic disparities in COVID-19-related infections, hospitalizations, and deaths : a systematic review.
      Further, the CDC’s COVID-Associated Hospitalization Surveillance Network (COVID-NET) showed that Black and Latinx populations have more than four times higher risk of hospitalizations than their White counterparts.
      • Mackey K.
      • Ayers C.K.
      • Kondo K.K.
      • et al.
      Racial and ethnic disparities in COVID-19-related infections, hospitalizations, and deaths : a systematic review.
      The racial/ethnic differences in hospitalization risk were also seen in the elderly. Among Medicare and Medicaid beneficiaries, an analysis of over 1.6 million COVID-19 hospitalizations showed that Indigenous, Black, and Latinx populations had 1.5 to 2.3 times higher hospitalization rates than White populations.
      Centers for Medicare and Medicaid Services
      Preliminary Medicare COVID-19 data snapshot.
      Minority communities also have higher mortality rates from COVID-19 than White communities. Although there is substantial variability across states, aggregate data demonstrate that the risk of death from COVID-19 was significantly higher in Black (standardized mortality ratio [SMR] = 3.57) and Latinx (SMR = 1.88) populations than in White populations.
      • Gross C.P.
      • Essien U.R.
      • Pasha S.
      • et al.
      Racial and ethnic disparities in population-level covid-19 mortality.
      A systematic review including American Public Media data corroborated the increased mortality in minorities, reporting the following rate ratios for minority groups compared with Whites: Asian, 1.2; Pacific Islanders, 2.4; Indigenous, 3.1; Black, 3.2; and Latinx, 3.2.
      • Mackey K.
      • Ayers C.K.
      • Kondo K.K.
      • et al.
      Racial and ethnic disparities in COVID-19-related infections, hospitalizations, and deaths : a systematic review.
      Such mortality risk was particularly striking in non-elderly individuals. Among individuals younger than 65 years, the percentage of Latinx (35%) and non-White (30%) individuals who died from COVID-19 was much higher than that in Whites (13%).
      • Wortham J.M.
      • Lee J.T.
      • Althomsons S.
      • et al.
      Characteristics of persons who died with COVID-19 - United States, february 12-may 18, 2020.
      Consistent with these differences, the risk of death from COVID-19 was ∼7 to 9 times higher in Black individuals aged 25 to 54 years than that in Whites in the same age group.
      • Bassett M.T.
      • Krieger N.
      • Chen J.T.
      Increased mortality risk estimates (ranging from 5.5 to 7.9) were also reported for Latinx individuals aged 25 to 54 years.
      • Bassett M.T.
      • Krieger N.
      • Chen J.T.
      Thus, Black and Latinx individuals lost more years of potential life than their White counterparts. The estimated years of potential life lost using a cutoff point of 65 years were 33,446, 45,777, and 48,204 years for White, Black, and Latinx people.
      • Bassett M.T.
      • Krieger N.
      • Chen J.T.
      Structural factors, including neighborhood type, contributed to health disparities in COVID-19 outcomes. Among the boroughs of New York City, the Bronx (which has the highest proportion of Black and Latinx residents) and Manhattan have the lowest and highest average income, respectively. Illustrating the impact of economic disadvantage on health outcomes, the Bronx and Manhattan also had the highest (224 per 100,000) and lowest (122 per 100,000) mortality rates from COVID-19.
      • Wadhera R.K.
      • Wadhera P.
      • Gaba P.
      • et al.
      Variation in COVID-19 hospitalizations and deaths across New York city boroughs.
      Further, patients cared for in New York’s less-resourced, community hospitals were three times more likely to die that those cared for at well-resourced hospitals.
      • Kelly C.
      • Parker W.F.
      • Pollack H.A.
      Low-income COVID-19 patients die needlessly because they are stuck in the wrong hospitals—while the right hospitals too often shut them out.
      A multicenter study of 65 medical centers across the US demonstrated that patients admitted to hospitals with fewer (<50 beds) intensive care units (ICU) beds had a higher risk of death than those admitted to hospitals with higher number (≥100 beds) of ICU beds (odds ratio [OR] = 3.28, 95% confidence interval [CI] = 2.16 to 4.99),
      • Gupta S.
      • Hayek S.S.
      • Wang W.
      • et al.
      Factors associated with death in critically ill patients with coronavirus disease 2019 in the US.
      exposing health care system failures that may continue to contribute to mortality during times of capacity strain (eg, influenza season) well after the COVID-19 pandemic.
      Structural discrimination limits employment and education opportunities for minority communities in the United States, ultimately limiting their socioeconomic growth.
      • Bailey Z.D.
      • Krieger N.
      • Agenor M.
      • et al.
      Structural racism and health inequities in the USA: evidence and interventions.
      In the first year of the pandemic, US counties with a higher proportion of residents who were Black, who had less than a high school diploma education, or who had lower household income reported more deaths from COVID-19 than other counties.
      • Khanijahani A.
      Racial, ethnic, and socioeconomic disparities in confirmed COVID-19 cases and deaths in the United States: a county-level analysis as of November 2020.
      ,
      • Tan A.X.
      • Hinman J.A.
      • Abdel Magid H.S.
      • et al.
      Association between income inequality and county-level COVID-19 cases and deaths in the US.
      In addition, language barriers impacted COVID-19 outcomes, as ecological studies showed that counties with a greater proportion of minorities and non-English-speaking people had increased COVID-19 mortality.
      • Khazanchi R.
      • Beiter E.R.
      • Gondi S.
      • et al.
      County-level association of social vulnerability with COVID-19 cases and deaths in the USA.
      Although further data on these "invisible" non-English-speaking communities are needed, language barriers might be considered a key social determinant of health in the United States.

      Disparities in Coronavirus Disease-2019 Care

      At the beginning of the pandemic, a study in Louisiana showed that Black patients were more likely to be on Medicaid, to be hospitalized, and to be tested for COVID-19 in the emergency department than White patients, who were more often diagnosed by a primary care provider.
      • Price-Haywood E.G.
      • Burton J.
      • Fort D.
      • et al.
      Hospitalization and mortality among black patients and white patients with covid-19.
      In Los Angeles, the case fatality rate for COVID-19 patients requiring intubation was higher for a low-resourced safety-net hospital than that for a well-resourced academic hospital. This facility regularly serves mostly Black and economically disadvantaged populations and during the winter 2020 to 2021 COVID-19 surge, most patients who died at this safety-net hospital were Latinx.
      • Kelly C.
      • Parker W.F.
      • Pollack H.A.
      Low-income COVID-19 patients die needlessly because they are stuck in the wrong hospitals—while the right hospitals too often shut them out.
      Similarly, during the November 2020 surge in Chicago, small community hospitals that predominantly care for Medicaid beneficiaries or uninsured populations were overwhelmed by the number and complexity of patients, whereas large academic hospitals had open intensive care unit beds. Such disparities in health care can be attributed to longstanding unaddressed issues such as structural racism,
      • Kelly C.
      • Parker W.F.
      • Pollack H.A.
      Low-income COVID-19 patients die needlessly because they are stuck in the wrong hospitals—while the right hospitals too often shut them out.
      the totality of ways in which societies foster racial discrimination through mutually reinforcing systems of housing, education, employment, earnings, benefits, credit, media, health care, and criminal justice. Such patterns and practices in turn reinforce discriminatory beliefs, values, and distribution of resources.
      • Bailey Z.D.
      • Krieger N.
      • Agenor M.
      • et al.
      Structural racism and health inequities in the USA: evidence and interventions.
      Racial health disparities are rooted in the Jim Crow Laws (eg, a collection of state and local statutes that legalized racial discrimination, starting after the Civil War, and continuing until 1965), when health care institutions were segregated by law. Following the Civil Rights Act of 1964
      • Krishnan L.
      • Ogunwole S.M.
      • Cooper L.A.
      Historical insights on coronavirus disease 2019 (COVID-19), the 1918 influenza pandemic, and racial disparities: illuminating a path forward.
      ,
      • Hua C.L.
      • Bardo A.R.
      • Brown J.S.
      Mistrust in physicians does not explain black-white disparities in primary care and emergency department utilization: the importance of socialization during the Jim Crow era.
      Medicare mandated that US hospitals receiving federal funding were racially integrated, yet today many hospitals in predominantly Black communities still operate with lower revenues because of charity care, limiting resources for staffing, training, and quality improvement initiatives, and reducing their capacity to respond to increased care needs. All this likely led to worse COVID-19 outcomes among Black communities in the US Southeast.
      • Krishnan L.
      • Ogunwole S.M.
      • Cooper L.A.
      Historical insights on coronavirus disease 2019 (COVID-19), the 1918 influenza pandemic, and racial disparities: illuminating a path forward.
      ,
      • Hua C.L.
      • Bardo A.R.
      • Brown J.S.
      Mistrust in physicians does not explain black-white disparities in primary care and emergency department utilization: the importance of socialization during the Jim Crow era.
      Language barriers can impede optimal health care. In the United States, over 25 million people report "limited English poficiency" (LEP) and may thus require interpreter services during medical encounters.
      • Herzberg E.M.
      • Barrero-Castillero A.
      • Matute J.D.
      The healing power of language: caring for patients with limited English proficiency and COVID-19.
      LEP affects access and use of health care and communication with health care providers, which can worsen health outcomes such as hospitalization length.
      • Flores G.
      The impact of medical interpreter services on the quality of health care: a systematic review.
      Title VI of the Civil Rights Act of 1964 requires health care institutions to provide language services for people with LEP, a task facilitated by recording the patients’ preferred language in the medical record and using technology to increase the availability of interpreters (eg, video and telephone).
      • Office of Civil Rights
      Guidance to federal financial assistance recipients regarding title vi and the prohibition against national origin discrimination affecting limited English proficient persons - summary.
      However, many health care systems still struggle to ensure appropriate interpreter services,
      • Flores G.
      • Torres S.
      • Holmes L.J.
      • et al.
      Access to hospital interpreter services for limited English proficient patients in New Jersey: a statewide evaluation.
      ,
      • Ryan J.
      • Abbato S.
      • Greer R.
      • et al.
      Rates and predictors of professional interpreting provision for patients with limited English proficiency in the emergency department and inpatient ward.
      a fact magnified during the COVID-19 pandemic.
      During the initial COVID-19 surge, interpreter services at an academic hospital in Boston could not meet the in-person language needs of the overwhelming number of patients with LEP, predominantly Spanish-speaking patients. Although the challenge prompted physicians to create a Spanish Language Care Group in response to the crisis, improving health care for people with LEP requires a multipronged approach. Such an approach includes expanding access to language services by increasing their reimbursement and maximizing their availability.
      • Herzberg E.M.
      • Barrero-Castillero A.
      • Matute J.D.
      The healing power of language: caring for patients with limited English proficiency and COVID-19.
      Speaking the patients' language (Fig. 4) and having a culturally humble approach to their concerns is a powerful component of care for non-English-speaking populations.
      Figure thumbnail gr4
      Fig. 4Spanish-speaking mother at an English-speaking-only vaccination site.
      (Courtesy of A. Payá Mora, BS, Santiago, Chile.)

      Disparities in Coronavirus Disease-2019 Vaccination

      The development of vaccines was a breakthrough in the fight against the COVID-19 pandemic, as they proved effective in reducing the risk of severe disease, hospitalization, and death. As of May 2022, 257.8 million (∼78%) of 330 million people in the United States had received at least one dose of a COVID-19 vaccine, and slightly less than a third of those vaccinated had received at least one additional dose (booster). Despite the disproportionate burden of COVID-19 on minority populations, only 48% of Black individuals and 63% of Latinx individuals had received at least one vaccine dose. Surveys have shown that vaccine uptake was lower among Black participants than White participants, even in those who self-reported willingness to get the vaccine.
      • Nguyen L.H.
      • Joshi A.D.
      • Drew D.A.
      • et al.
      Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom.
      Vaccination hesitancy has decreased in Black populations
      • Funk C.
      • Tyson A.
      Pew Research Center
      Growing share of Americans say they plan to get a COVID-19 vaccine – or already have.
      but poverty and younger age (18 to 49 years) remain as risk factors for vaccine hesitancy in this group.
      • Nguyen K.H.
      • Anneser E.
      • Toppo A.
      • et al.
      Disparities in national and state estimates of COVID-19 vaccination receipt and intent to vaccinate by race/ethnicity, income, and age group among adults >/= 18 years, United States.
      Vaccination is an act of trust in science and the health care system. Minority survey participants reported that they did not trust the COVID-19 vaccine development process and wanted more transparent information, an attitude justified by prior abuses of trust by researchers and physicians.
      • Jimenez M.E.
      • Rivera-Nunez Z.
      • Crabtree B.F.
      • et al.
      Black and latinx community perspectives on COVID-19 mitigation behaviors, testing, and vaccines.
      The year 2022 marked the fiftieth anniversary of the uncovering of the Tuskegee syphilis study, in which Black participants were not given treatment of this life-threatening disease for decades despite substantial evidence of the therapy's efficacy.
      • Tobin M.J.
      Fiftieth anniversary of uncovering the tuskegee syphilis study: the story and timeless lessons.
      Researchers working for the same agency (the Public Health Service, a precursor of the CDC) that conducted the Tuskegee study purposely infected Guatemalan study participants with syphilis and gonorrhea to develop preventive methods for these infections.
      • Tobin M.J.
      Fiftieth anniversary of uncovering the tuskegee syphilis study: the story and timeless lessons.
      Contemporary vaccine hesitancy is not only explained by historical facts but also by ongoing instances of racism in health care. Black patients are more likely to have their pain negated, their illnesses misdiagnosed, and even treatment denied by health care providers.
      • Bajaj S.S.
      • Stanford F.C.
      Beyond tuskegee - vaccine distrust and everyday racism.
      Trust is earned through long-term patient-provider relationships and may be more easily built with racial concordance with health care providers. Black participants had increased information-seeking behavior after listening to videos about COVID-19 from Black physicians.
      • Alsan M.
      • Stanford F.C.
      • Banerjee A.
      • et al.
      Comparison of knowledge and information-seeking behavior after general COVID-19 public health messages and messages tailored for black and latinx communities : a randomized controlled trial.
      Language barriers are an important obstacle to vaccination efforts, even in people with LEP who have health insurance. A study of Medicare Advantage beneficiaries demonstrated that Latinx individuals with LEP were less likely to anticipate getting the vaccines than those with English proficiency, despite having a higher rate of a positive COVID-19 test.
      • Himmelstein J.
      • Himmelstein D.U.
      • Woolhandler S.
      • et al.
      COVID-19-Related care for hispanic elderly adults with limited English proficiency.
      This disparity was mainly attributed to differences in income but LEP was likely a contributory factor.
      • Himmelstein J.
      • Himmelstein D.U.
      • Woolhandler S.
      • et al.
      COVID-19-Related care for hispanic elderly adults with limited English proficiency.
      LEP, inadequate health literacy, and limited Internet access are potential barriers to online initiatives to increase vaccination rates in vulnerable populations, as one study showed that only 10.6% of patients with LEP scheduled an appointment through patient portals.
      • Fuchs J.R.
      • Fuchs J.W.
      • Tietz S.E.
      • et al.
      Older adults with limited English proficiency need equitable COVID-19 vaccine access.
      In the United States in 2018, 43.5 million people, 13.5% of the total population, are non-US born residents, of whom over 10 million were undocumented in 2021.

      Mulasi I. E Pluribus Unum. N Engl J Med. 386 (21), 2022, 1969-1971.

      Immigrants are more likely to have high-risk, essential jobs and less likely to seek medical care. Additional barriers to vaccination include lack of time off work, financial resources, and health insurance.

      Mulasi I. E Pluribus Unum. N Engl J Med. 386 (21), 2022, 1969-1971.

      Because vaccination sites often require documenting personal information, undocumented immigrants fear that their personal information might be shared with immigration authorities and that deportation may follow.
      • Diaz A.A.
      • Celedon J.C.
      COVID-19 vaccination: helping the latinx community to come forward.
      Thus, being an immigrant is both a risk factor for COVID-19 and non-vaccination status in the United States.

      Lesson Learned and Opportunities for Action

      Improving access to health care

      In the United States, the COVID-19 pandemic further exposed profound health disparities caused by structural and social determinants, such as racism and misguided policies on education, health, and housing.
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      As a society, we must commit to providing medical care for all. Curbing disease outbreaks requires treating all people based on their health needs, regardless of insurance status, race or ethnicity, immigration status, and other attributes. Although implementing medical care will require a considerable investment of money, time, and resources, health equity leads to enormous cost savings and improved overall health in the long term.
      • LaVeist T.A.
      • Gaskin D.
      • Richard P.
      Estimating the economic burden of racial health inequalities in the United States.
      • Celedon J.C.
      • Roman J.
      • Schraufnagel D.E.
      • et al.
      Respiratory health equality in the United States. The American thoracic society perspective.
      • Bhatt J.
      • Batra N.
      • Davis A.
      • et al.
      In the absence of universal health care, short-term policies are needed to mitigate the impact of the pandemic in underserved groups. First, economically disadvantaged communities should continue to receive cash benefits for COVID-related expenses from state and federal sources, and such benefits should be clearly outlined by health care providers serving historically marginalized, underserved communities.
      • Page K.R.
      • Flores-Miller A.
      Lessons we've learned - covid-19 and the undocumented latinx community.
      This reassurance is relevant, as fear of medical bills can lead to avoidance or delays in seeking preventive and therapeutic care. Second, the Affordable Care Act should be expanded to cover COVID-19 care, including emergency department visits, hospitalizations, and access to virtual services, would improve outcomes in historically disadvantaged communities.
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      Third, safety-net hospitals that care for the urban poor—a group predominantly composed of Black, Latinx, and immigrant populations—should receive adequate resources (eg, protective equipment, equipment for intensive care units, medical and nonmedical staff) to face the health crisis posed by the current pandemic and foreseeable potential catastrophes.
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      Fourth, hospitals and academic institutions should clearly state and improve upon their charity policies. COVID-19 mortality seemed to be higher in counties with predominantly non-English communities, a group mainly composed of low-income immigrants.
      • Khazanchi R.
      • Beiter E.R.
      • Gondi S.
      • et al.
      County-level association of social vulnerability with COVID-19 cases and deaths in the USA.
      Fifth, migrants and refugees should receive culturally and language-appropriate care, including for vaccinations. Although data on this vulnerable population are not routinely collected, making them an invisible group, leaders of vaccination campaigns must clarify that personal information is kept confidential to avoid vaccination hesitancy due to fear of deportation.

      Tackling Racism and Implicit Biases

      In the United States, the racial injustices and subsequent protests that occurred during the pandemic highlighted the continued negative impact of structural racism on our society.
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      Scientific evidence has linked structural racism, such as historical redlining of neighborhoods, to unequal environmental exposures leading to a heavy burden of asthma in Black communities.
      • Schuyler A.J.
      • Wenzel S.E.
      Historical redlining impacts contemporary environmental and asthma-related outcomes in black adults.
      During the pandemic, movements to address ethno-racial inequities through implicit bias training and implementation of equity, diversity, and inclusion efforts were invigorated at the community level and at academic hospitals and in medical societies.
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      As researchers, educators, and health care providers, we can explicitly tackle disparities at the individual level. For instance, we can apply processes to select trainees and faculty to better represent the rich diversity of our society and provide financial compensation to support these individuals.
      • Thakur N.
      • Lovinsky-Desir S.
      • Bime C.
      • et al.
      The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
      To better serve migrants and refugees, medical institutions should consider sponsoring highly qualified immigrant trainees.

      Job Protections

      Essential workers, who take the risk of keeping our society functioning, need job protections, such as paid medical leave and child and elder care support. State and local officials should implement policies and work with employers to protect frontline workers and give appropriate paid medical leave.

      Improving Communication and Facilitating Access to Vaccines

      Messaging about COVID-19 preventive measures, testing resources, vaccines, and general guidance should consider strategies for populations with low health literacy and in multiple languages to reach people with LEP. The use of trusted messengers is one strategy to provide accurate information and has proven to encourage behavior changes, such as seeking information about COVID-19.
      • Diaz A.A.
      • Celedon J.C.
      COVID-19 vaccination: helping the latinx community to come forward.
      ,
      • Alsan M.
      • Stanford F.C.
      • Banerjee A.
      • et al.
      Comparison of knowledge and information-seeking behavior after general COVID-19 public health messages and messages tailored for black and latinx communities : a randomized controlled trial.
      Vaccination rates should continue to rise for all, as vaccine boosters are needed to keep protection against COVID-19. Using non-English-speaking personnel at vaccination sites, giving transportation vouchers and incentives, employing navigators to help with online appointments, and installing vaccination sites in disadvantaged neighborhoods are some strategies that could increase vaccination rates.

      Summary

      The COVID-19 pandemic has disproportionally affected historically marginalized communities, such as minority populations, immigrants, and economically disadvantaged individuals. Black, Latinx, and Indigenous people have higher rates of COVID-19 infections, hospitalizations, and deaths than White populations. The pandemic has exacerbated health disparities rooted in historical structural inequalities that our society has chosen to neglect. Thus, policies that tackle structural inequities (racism, housing, education), ensure access to health care and health information, and protect vulnerable populations should be prioritized. Preventive and therapeutic care for COVID-19 should be provided through an equity lens to ensure that everybody is treated and protected based on their unique needs. Reducing the devastating effects of the ongoing COVID-19 pandemic on underserved and historically disadvantaged communities should be a high priority in our journey to achieve health equity and social justice.

      Funding/support

      Dr A.A. Diaz is supported by funding from the US National Heart, Lung, and Blood Institute (R01-HL133137, R01-HL14986, R01-HL164824) and the Brigham and Women’s Hospital Minority Faculty Career Development Award. Dr N. Thakur is supported by funding from the US National Institutes of Health (R01-HL161049), Robert Wood Johnson Foundation, United States, and the Nina Ireland Program for Lung Health. Dr J.C. Celedón is supported by grants HL117191 and HL152475 from the US National Institutes of Health.

      Disclosure

      Dr A.A. Diaz declares speaker fees from Boehringer Ingelheim outside of submitted work; Dr N. Thakur has no disclosures to declare. Dr J.C. Celedón reports research materials from Pharmavite (vitamin D and placebo capsules), and GSK and Merck (inhaled steroids) to provide medications free of charge to participants in his NIH-funded studies, outside of this submitted work.

      Acknowledgments

      The authors thank Ms Anastasia Payá Mora for creating Fig. 4. Note: To test oneself and learn about implicit bias, visit https://implicit.harvard.edu.

      References

        • Center for Disease Control and Prevention
        United States COVID-19 cases, deaths, and laboratory testing (NAATs) by state, territory, and jurisdiction.
        (Available at:) (Accessed on 2 June 2022)
        • Mackey K.
        • Ayers C.K.
        • Kondo K.K.
        • et al.
        Racial and ethnic disparities in COVID-19-related infections, hospitalizations, and deaths : a systematic review.
        Ann Intern Med. 2021; 174: 362-373
        • Hatcher S.M.
        • Agnew-Brune C.
        • Anderson M.
        • et al.
        COVID-19 among American Indian and Alaska native persons - 23 states, january 31-july 3, 2020.
        MMWR Morb Mortal Wkly Rep. 2020; 69: 1166-1169
        • Wortham J.M.
        • Lee J.T.
        • Althomsons S.
        • et al.
        Characteristics of persons who died with COVID-19 - United States, february 12-may 18, 2020.
        MMWR Morb Mortal Wkly Rep. 2020; 69: 923-929
      1. USA Facts. US Coronavirus vaccine tracker.
        (Available at:) (Accessed June 3, 2022)
        • Diaz A.A.
        • Celedon J.C.
        COVID-19 vaccination: helping the latinx community to come forward.
        EClinicalMedicine. 2021; 35: 100860
        • Thakur N.
        • Lovinsky-Desir S.
        • Bime C.
        • et al.
        The structural and social determinants of the racial/ethnic disparities in the U.S. COVID-19 pandemic. What's our role?.
        Am J Respir Crit Care Med. 2020; 202: 943-949
        • Solar O.
        • Inwin A.
        A conceptual framework for action on the social determinants of health: social determinants of health discussion paper 2.
        World Health Organization, Geneva, Switzerland2010
        • Moore J.T.
        • Ricaldi J.N.
        • Rose C.E.
        • et al.
        Disparities in incidence of COVID-19 among underrepresented racial/ethnic groups in counties identified as hotspots during June 5–18, 2020 — 22 states february–june 2020.
        MMWR Morb Mortal Wkly Rep. 2020; 69: 1122-1126
      2. Chow DS, Soun J, Gavis-Bloom J, et al. The disproportionate rise in COVID-19 cases among Hispanic/Latinx in disadvantaged communities of Orange County, California: A socioeconomic case-series. Pre-print. Posted online on 7 May 2020. medRxiv. doi: 10.1101/2020.05.04.20090878.

        • Okoh A.K.
        • Sossou C.
        • Dangayach N.S.
        • et al.
        Coronavirus disease 19 in minority populations of Newark, New Jersey.
        Int J Equity Health. 2020; 19: 93
        • Adegunsoye A.
        • Ventura I.B.
        • Liarski V.M.
        Association of black race with outcomes in COVID-19 disease: a retrospective cohort study.
        Ann Am Thorac Soc. 2020; 17: 1336-1339
        • Center for Disease Control and Prevention
        COVID-19 weekly cases and deaths per 100,000 population by age, race/ethnicity, and sex.
        (Available at:) (Accessed June 3, 2022)
        • Himmelstein K.E.W.
        • Venkataramani A.S.
        Economic vulnerability among us female health care workers: potential impact of a $15-per-hour minimum wage.
        Am J Public Health. 2019; 109: 198-205
        • Anderson M.
        Who relies on public transit in the U.S. Pew Research Center.
        (Available at:) (Accessed June 27, 2022)
        • Alsan M.
        • Stantcheva S.
        • Yang D.
        • et al.
        Disparities in coronavirus 2019 reported incidence, knowledge, and behavior among US adults.
        JAMA Netw Open. 2020; 3: e2012403
        • Page K.R.
        • Flores-Miller A.
        Lessons we've learned - covid-19 and the undocumented latinx community.
        N Engl J Med. 2021; 384: 5-7
        • Centers for Medicare and Medicaid Services
        Preliminary Medicare COVID-19 data snapshot.
        (Available at:) (Accessed June 2, 2022)
        • Gaffney A.W.
        • Hawks L.
        • Bor D.H.
        • et al.
        18.2 million individuals at increased risk of severe COVID-19 illness are un- or underinsured.
        J Gen Intern Med. 2020; 35: 2487-2489
        • Artiga S.
        • Hill L.
        • Orgera K.
        • et al.
        Health coverage by race and ethnicity, 2010-2019.
        (Available at:) (Accessed June 3, 2022)
        • Khazanchi R.
        • Beiter E.R.
        • Gondi S.
        • et al.
        County-level association of social vulnerability with COVID-19 cases and deaths in the USA.
        J Gen Intern Med. 2020; 35: 2784-2787
        • Centers for Disease Control and Prevention
        COVID view summary ending on June 20, 2020.
        (Available at:) (Accessed July 20, 2020)
        • Gold J.A.W.
        • Wong K.K.
        • Szablewski C.M.
        • et al.
        Characteristics and clinical outcomes of adult patients hospitalized with COVID-19 - Georgia, March 2020.
        MMWR Morb Mortal Wkly Rep. 2020; 69: 545-550
        • Hsu H.E.
        • Ashe E.M.
        • Silverstein M.
        • et al.
        Race/ethnicity, underlying medical conditions, homelessness, and hospitalization status of adult patients with COVID-19 at an urban safety-net medical center - Boston, Massachusetts, 2020.
        MMWR Morb Mortal Wkly Rep. 2020; 69: 864-869
        • Gross C.P.
        • Essien U.R.
        • Pasha S.
        • et al.
        Racial and ethnic disparities in population-level covid-19 mortality.
        J Gen Intern Med. 2020; 35: 3097-3099
        • Bassett M.T.
        • Krieger N.
        • Chen J.T.
        The unequal toll of COVID-19 mortality by age in the United States: quantifying racial/ethnic disparities.
        (Available at:) (Accessed on 20 July 20. Accessed)
        • Wadhera R.K.
        • Wadhera P.
        • Gaba P.
        • et al.
        Variation in COVID-19 hospitalizations and deaths across New York city boroughs.
        JAMA. 2020; 323: 2192-2195
        • Kelly C.
        • Parker W.F.
        • Pollack H.A.
        Low-income COVID-19 patients die needlessly because they are stuck in the wrong hospitals—while the right hospitals too often shut them out.
        (Available at:) (Accessed Jun 13, 2022)
        • Gupta S.
        • Hayek S.S.
        • Wang W.
        • et al.
        Factors associated with death in critically ill patients with coronavirus disease 2019 in the US.
        JAMA Intern Med. 2020; 180: 1436-1447
        • Bailey Z.D.
        • Krieger N.
        • Agenor M.
        • et al.
        Structural racism and health inequities in the USA: evidence and interventions.
        Lancet. 2017; 389: 1453-1463
        • Khanijahani A.
        Racial, ethnic, and socioeconomic disparities in confirmed COVID-19 cases and deaths in the United States: a county-level analysis as of November 2020.
        Ethn Health. 2021; 26: 22-35
        • Tan A.X.
        • Hinman J.A.
        • Abdel Magid H.S.
        • et al.
        Association between income inequality and county-level COVID-19 cases and deaths in the US.
        JAMA Netw Open. 2021; 4: e218799
        • Price-Haywood E.G.
        • Burton J.
        • Fort D.
        • et al.
        Hospitalization and mortality among black patients and white patients with covid-19.
        N Engl J Med. 2020; 382: 2534-2543
        • Krishnan L.
        • Ogunwole S.M.
        • Cooper L.A.
        Historical insights on coronavirus disease 2019 (COVID-19), the 1918 influenza pandemic, and racial disparities: illuminating a path forward.
        Ann Intern Med. 2020; 173: 474-481
        • Hua C.L.
        • Bardo A.R.
        • Brown J.S.
        Mistrust in physicians does not explain black-white disparities in primary care and emergency department utilization: the importance of socialization during the Jim Crow era.
        J Natl Med Assoc. 2018; 110: 540-546
        • Herzberg E.M.
        • Barrero-Castillero A.
        • Matute J.D.
        The healing power of language: caring for patients with limited English proficiency and COVID-19.
        Pediatr Res. 2022; 91: 526-528
        • Flores G.
        The impact of medical interpreter services on the quality of health care: a systematic review.
        Med Care Res Rev. 2005; 62: 255-299
        • Office of Civil Rights
        Guidance to federal financial assistance recipients regarding title vi and the prohibition against national origin discrimination affecting limited English proficient persons - summary.
        (Available at:) (Accessed June 2, 2022)
        • Flores G.
        • Torres S.
        • Holmes L.J.
        • et al.
        Access to hospital interpreter services for limited English proficient patients in New Jersey: a statewide evaluation.
        J Health Care Poor Underserved. 2008; 19: 391-415
        • Ryan J.
        • Abbato S.
        • Greer R.
        • et al.
        Rates and predictors of professional interpreting provision for patients with limited English proficiency in the emergency department and inpatient ward.
        Inquiry. 2017; 54 (46958017739981)
        • Nguyen L.H.
        • Joshi A.D.
        • Drew D.A.
        • et al.
        Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom.
        Nat Commun. 2022; 13: 636
        • Funk C.
        • Tyson A.
        • Pew Research Center
        Growing share of Americans say they plan to get a COVID-19 vaccine – or already have.
        (Available at:) (Accessed June 3, 2022)
        • Nguyen K.H.
        • Anneser E.
        • Toppo A.
        • et al.
        Disparities in national and state estimates of COVID-19 vaccination receipt and intent to vaccinate by race/ethnicity, income, and age group among adults >/= 18 years, United States.
        Vaccine. 2022; 40: 107-113
        • Jimenez M.E.
        • Rivera-Nunez Z.
        • Crabtree B.F.
        • et al.
        Black and latinx community perspectives on COVID-19 mitigation behaviors, testing, and vaccines.
        JAMA Netw Open. 2021; 4: e2117074
        • Tobin M.J.
        Fiftieth anniversary of uncovering the tuskegee syphilis study: the story and timeless lessons.
        Am J Respir Crit Care Med. 2022; 205: 1145-1158
        • Bajaj S.S.
        • Stanford F.C.
        Beyond tuskegee - vaccine distrust and everyday racism.
        N Engl J Med. 2021; 384: e12
        • Alsan M.
        • Stanford F.C.
        • Banerjee A.
        • et al.
        Comparison of knowledge and information-seeking behavior after general COVID-19 public health messages and messages tailored for black and latinx communities : a randomized controlled trial.
        Ann Intern Med. 2021; 174: 484-492
        • Himmelstein J.
        • Himmelstein D.U.
        • Woolhandler S.
        • et al.
        COVID-19-Related care for hispanic elderly adults with limited English proficiency.
        Ann Intern Med. 2022; 175: 143-145
        • Fuchs J.R.
        • Fuchs J.W.
        • Tietz S.E.
        • et al.
        Older adults with limited English proficiency need equitable COVID-19 vaccine access.
        J Am Geriatr Soc. 2021; 69: 888-891
        • United States Census Bureau
        Narrative profiles: 2014-2018 American community surevy.
        (Accessed Aug 3, 2022)
      3. Mulasi I. E Pluribus Unum. N Engl J Med. 386 (21), 2022, 1969-1971.

        • LaVeist T.A.
        • Gaskin D.
        • Richard P.
        Estimating the economic burden of racial health inequalities in the United States.
        Int J Health Serv. 2011; 41: 231-238
        • Celedon J.C.
        • Roman J.
        • Schraufnagel D.E.
        • et al.
        Respiratory health equality in the United States. The American thoracic society perspective.
        Ann Am Thorac Soc. 2014; 11: 473-479
        • Bhatt J.
        • Batra N.
        • Davis A.
        • et al.
        US health care can’t afford health inequities.
        (Available at:) (Accessed June 24, 2022)
        • Schuyler A.J.
        • Wenzel S.E.
        Historical redlining impacts contemporary environmental and asthma-related outcomes in black adults.
        Am J Respir Crit Care Med. 2022; 206: 824-837