Sarcoidosis is a multigenic and multifactorial disease. Predisposing genes have been
identified and fast progress in molecular technologies including systematic genome-wide
association studies and large-scale resequencing will aid the discovery of further
risk loci and variants. The exploration of the molecular epidemiology of genetic variants
in the pathogenesis of sarcoidosis will allow an assessment of their prognostic usefulness.
To this end, different granulomatous disorders of known and unknown etiology should
be investigated jointly by genetic, immunobiological, and proteomic approaches. The
definition of individual genetic risk profiles in sarcoidosis and other chronic inflammatory
disorders seems achievable and a useful route for clinical translation.
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Article info
Footnotes
This work was supported by a Grant No. 01GS0426 of the National Genome Research Network Germany and Grant No. Mu 692/7-1 of the Deutsche Forschungsgemeinschaft, Bonn, Germany.
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© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
