Clinics in Chest Medicine
Volume 30, Issue 2 , Pages 203-215, June 2009

Overview of Antifungal Agents

  • George R. Thompson III, MD, FACP

      Affiliations

    • Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    • Department of Internal Medicine, Division of Infectious Diseases, South Texas Veterans Health Care System, 7400 Merton Minter Drive, San Antonio, TX 78229, USA
    • Corresponding Author InformationCorresponding author. Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229.
    • ,
  • Jose Cadena, MD

      Affiliations

    • Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    • Department of Internal Medicine, Division of Infectious Diseases, South Texas Veterans Health Care System, 7400 Merton Minter Drive, San Antonio, TX 78229, USA
    • ,
  • Thomas F. Patterson, MD

      Affiliations

    • Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    • Department of Internal Medicine, Division of Infectious Diseases, South Texas Veterans Health Care System, 7400 Merton Minter Drive, San Antonio, TX 78229, USA

This article is a comprehensive clinically focused review of currently available antifungals administered by way of the intravenous or inhalational route: amphotericin B and its lipid formulations, fluconazole, itraconazole, posaconazole, voriconazole, caspofungin, micafungin, anidulafungin, and flucytosine. Emphasis is placed on pharmacodynamics and kinetics, drug interactions, adverse events, and evidence for their use. Selected clinical trials demonstrating the efficacy of these agents are also reviewed.

Keywords: Fungal infection, Invasive mycoses, Triazoles, Echinocandins, Amphotericin, Flucytosine

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PII: S0272-5231(09)00014-8

doi:10.1016/j.ccm.2009.02.001

Clinics in Chest Medicine
Volume 30, Issue 2 , Pages 203-215, June 2009

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